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Vaccine by Nov. 3? Halted study explains just how unlikely

WASHINGTON (AP) — The suspension of a huge COVID-19 vaccine study over an illness in a single participant shows there will be “no compromises” on safety in the race to develop the shot, the chief of the National Institutes of Health told Congress on Wednesday.

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Global death toll from the coronavirus has surpassed 900,000--NYTimes roundup

The global death toll from the coronavirus has surpassed 900,000, according to a New York Times database, and sickened at least 27.8 million people as of Thursday morning.

Seven months into the pandemic, the virus has been detected in almost every country.

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Why COVID-19 is more deadly in people with obesity—even if they're young

Since the pandemic began, dozens of studies have reported that many of the sickest COVID-19 patients have been people with obesity. In recent weeks, that link has come into sharper focus as large new population studies have cemented the association and demonstrated that even people who are merely overweight are at higher risk.

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WHO says vaccine safety top priority, as AstraZeneca pauses study

ZURICH/GENEVA (Reuters) - Safety of a prospective COVID-19 vaccine comes "first and foremost", the World Health Organization's chief scientist said on Wednesday, as a trial of a leading candidate from AstraZeneca was paused due to concerns over side effects.

Rollout of an effective vaccine is seen as a crucial step in helping battered economies recover from the coronavirus pandemic.

"Just because we talk about speed...it doesn't mean we start compromising or cutting corners on what would normally be assessed," Dr. Soumya Swaminathan said in a social media event.

"The process still has to follow through rules of the game. For drugs and vaccines which are given to people, you have to test their safety, first and foremost," she said.

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How the Aging Immune System Makes Older People Vulnerable to Covid-19

Covid-19 patients who are 80 or older are hundreds of times more likely to die than those under 40.

That’s partly because they are more likely to have underlying conditions — like diabetes and lung disease — that seem to make the body more vulnerable to Covid-19.

But some scientists suggest another likely, if underappreciated, driver of this increased risk: the aging immune system.

The changes that ripple through our network of immune cells as the decades pass are complex, resulting in an overreaction here, a delayed response there and over all, a strangely altered landscape of immunity.

Scientists who study the aging immune system say that understanding it may lead not only to a clearer sense of how age is connected to disease vulnerability, but to better strategies for vaccines and treatments for Covid-19.

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